If Isaac Newton suddenly popped out of a time machine, he’d be delighted to see how far physics had come. Things that were deeply mysterious a few centuries ago are now taught in freshman physics classes (the composition of stars is one good example).


Newton would be stunned to see enormous experiments like the Large Hadron Collider (LHC) in Switzerland - and possibly perturbed to learn that his theory of gravity had been superseded by one dreamed up by some fellow named Einstein. Quantum mechanics would probably strike him as bizarre, though today’s scientists feel the same way.


But once he was up to speed, Newton would no doubt applaud what modern physics has achieved - from the discovery of the nature of light in the 19th Century to determining the structure of the atom in the 20th Century to last year’s discovery of gravitational waves. And yet physicists today are the first to admit they don’t have all the answers. “There are basic facts about the universe that we’re ignorant of,” says Dr. Daniel Whiteson, a University of California physicist and the co-author of the new book "We Have No Idea: A Guide to the Unknown Universe."


What follows is a brief tour through seven of the biggest unsolved problems in physics. (If you’re wondering why head-scratchers like dark matter and dark energy aren’t on the list, it’s because they were in our earlier story on the Five Biggest Questions about the Universe.)


1. What is matter made of?


We know matter is made up atoms, and atoms are made up of protons, neutrons, and electrons. And we know that protons and neutrons are made up of smaller particles known as quarks. Would probing deeper uncover particles even more fundamental? We don't know for sure.


We do have something called the Standard Model of particle physics, which is very good at explaining the interactions between subatomic particles. The Standard Model has also been used to predict the existence of previously unknown particles. The last particle to be found this way was the Higgs boson, which LHC researchers discovered in 2012.


But there’s a hitch.


“The Standard Model doesn’t explain everything,” says Dr. Don Lincoln, a particle physicist at Fermi National Accelerator Laboratory (Fermilab) near Chicago. “It doesn’t explain why the Higgs boson exists. It doesn’t explain in detail why the Higgs boson has the mass that it does.” In fact, the Higgs turned out to be a heck of a lot less massive than predicted - theory had held that it would be about “a quadrillion times heavier than it is,” says Lincoln.

One of the particle detectors in CERN's Large Hadron Collider.

One of the particle detectors in CERN's Large Hadron Collider.Rex Features via AP


The mysteries don’t end there. Atoms are known to be electrically neutral - the positive charge of the protons is cancelled out by the negative charge of the electrons - but as to why this is so, Lincoln says, “Nobody knows.”


2. Why is gravity so weird?


No force is more familiar than gravity - it’s what keeps our feet on the ground, after all. And Einstein’s theory of general relativity gives a mathematical formulation for gravity, describing it as a “warping” of space. But gravity is a trillion trillion trillion times weaker than the other three known forces (electromagnetism and the two kinds of nuclear forces that operate over tiny distances).


One possibility - speculative at this point - is that in addition to the three dimensions of space that we notice every day, there are hidden extra dimensions, perhaps “curled up” in a way that makes them impossible to detect. If these extra dimensions exist - and if gravity is able to “leak” into them - it could explain why gravity seems so weak to us.


“It could be that gravity is as strong as these other forces but that it gets rapidly diluted by spilling out into these other invisible dimensions,” says Whiteson. Some physicists hoped that experiments at the LHC would give a hint of these extra dimensions - but so far, no luck.


3. Why does time seem to flow only in one direction?


Since Einstein, physicists have thought of space and time as forming a four-dimensional structure known as “spacetime.” But space differs from time in some very fundamental ways. In space, we’re free to move about as we wish. When it comes to time, we’re stuck. We grow older, not younger. And we remember the past, but not the future. Time, unlike space, seems to have a preferred direction - physicists call it the “arrow of time.”


Some physicists suspect that the second law of thermodynamics provides a clue. It states that the entropy of a physical system (roughly, the amount of disorder) rises over time, and physicists think this increase is what gives time its direction. (For example, a broken teacup has more entropy than an intact one - and, sure enough, smashed teacups always seem to arise after intact ones, not before.)


Entropy may be rising now because it was lower earlier, but why was it low to begin with? Was the entropy of the universe unusually low 14 billion years ago, when the Big Bang brought it into existence?


For some physicists, including Caltech’s Sean Carroll, that’s the missing piece of the puzzle. “If you can tell me why the early universe had a low entropy, then I can explain the rest of it,” he says. In Whiteson’s view, entropy isn't the whole story. “To me,” he says, “the deepest part of the question is, why is time so different from space?” (Recent computer simulations seem to show how the asymmetry of time might arise from the fundamental laws of physics, but the work is controversial, and the ultimate nature of time continues to stir passionate debate.)


4. Where did all the antimatter go?


Antimatter may be more famous in fiction than in real life. On the original Star Trek, antimatter reacts with ordinary matter to power the warp drive that propels the U.S.S. Enterprise at faster-than-light velocities. While warp drive is pure fiction, antimatter is very real. We know that for each particle of ordinary matter, it's possible to have an identical particle with the opposite electrical charge. An antiproton is just like a proton, for example, but with a negative charge. The antiparticle corresponding to the negatively charged electron, meanwhile, is the positively charged positron.


Physicists have created antimatter in the laboratory. But when they do, they create an equal amount of matter. That suggests that the Big Bang must have created matter and antimatter in equal quantities. Yet almost everything we see around us, from the ground beneath our feet to the most remote galaxies, is made of ordinary matter.


What’s going on? Why is there more matter than antimatter? Our best guess is that the Big Bang somehow produced a tiny bit more matter than antimatter. “What had to have happened early in the history of the universe - in the very moments after the Big Bang - is that for every 10 billion antimatter particles there were 10 billion and one matter particles,” says Lincoln. “And the matter and the antimatter annihilated the 10 billion, leaving the one. And that little ‘one’ is the mass that makes up us.”


But why the slight excess of matter over antimatter in the first place? “We really don’t understand that,” Lincoln says. “It’s bizarre.” Had the initial amounts of matter and antimatter been equal, they’d have annihilated each other completely in a burst of energy. In which case, says Lincoln, “we wouldn’t exist.”

Giovani Punzi

Fermi National Accelerator Laboratory in Batavia, Illinois.M. Spencer Green / AP file


Some answers may come when the Deep Underground Neutrino Experiment (DUNE) starts collecting data in 2026. DUNE will analyze a beam of neutrinos - tiny, chargeless and nearly massless particles - fired from Fermilab to the Sanford Underground Research Facility in South Dakota, some 800 miles away. The beam will include neutrinos and antineutrinos, with the aim of seeing if they behave in the same manner - thus potentially providing a clue to nature’s matter-antimatter asymmetry.


5. What happens in the gray zone between solid and liquid?


Solids and liquids are well understood. But some materials act like both a liquid and a solid, making their behavior hard to predict. Sand is one example. A grain of sand is as solid as a rock, but a million grains can flow through a funnel almost like water. And highway traffic can behave in a similar way, flowing freely until it becomes blocked at some bottleneck.

Image: Sand

 A grain of sand is as solid as a rock, but a million grains can flow through a funnel almost like water.Vladyslav Danilin / Getty Images


So a better understanding of this “gray zone” might have important practical applications.


“People have been asking, under what conditions does the entire system jam up or clog?” says Dr. Kerstin Nordstrom, a physicist at Mount Holyoke College. “What are the crucial parameters to avoid clogging?” Weirdly, an obstruction in the flow of traffic can, under certain conditions, actually reduce traffic jams. “It’s very counterintuitive,” she says.


6. Can we find a unified theory of physics?


We now have two overarching theories to explain just about every physical phenomenon: Einstein’s theory of gravity (general relativity) and quantum mechanics. The former is good at explaining the motion of everything from golf balls to galaxies. Quantum mechanics is equally impressive in its own domain - the realm of atoms and subatomic particles.


Trouble is, the two theories describe our world in very different terms. In quantum mechanics, events unfold against a fixed backdrop of spacetime - while in general relativity, spacetime itself is flexible. What would a quantum theory of curved space-time look like? We don’t know, says Carroll. “We don’t even know what it is we’re trying to quantize.”


That hasn’t stopped people from trying. For decades now, string theory - which pictures matter as made up of tiny vibrating strings or loops of energy - has been touted as the best bet for producing a unified theory of physics. But some physicists prefer loop quantum gravity, in which space itself is imagined to be made of tiny loops.


Each approach has enjoyed some success - techniques developed by string theorists, in particular, are proving useful for tackling certain difficult physics problems. But neither string theory or loop quantum gravity has been tested experimentally. For now, the long-sought “theory of everything” continues to elude us.


7. How did life evolve from nonliving matter?


For its first half-billion years, Earth was lifeless. Then life took hold, and it has thrived ever since. But how did life arise? Before biological evolution began, scientists believe there was chemical evolution, with simple inorganic molecules reacting to form complex organic molecules, most likely in the oceans. But what kick-started this process in the first place?


MIT physicist Dr. Jeremy England recently put forward a theory that attempts to explain the origin of life in terms of fundamental principles of physics. In this view, life is the inevitable result of rising entropy. If the theory is correct, the arrival of life “should be as unsurprising as rocks rolling downhill,” England told Quanta magazine in 2014.


The idea is highly speculative. Recent computer simulations, however, may be lending support to it. The simulations show that ordinary chemical reactions (of the sort that would have been common on the newly formed Earth) can lead to the creation of highly structured compounds - seemingly a crucial stepping-stone on the path to living organisms.

Aerial view of Lago Preto, Amazon Rainforest and lake, Peru

Once life took root on our planet, some four billion years ago, it spread everywhere. But how life evolved fro non-living matter remains a mystery.Mark Bowler / Nature Picture Library/Getty Images


What makes life so hard for physicists to study? Anything that’s alive is “far from equilibrium,” as a physicist would put it. In a system in equilibrium, one component is pretty much like every other, with no flow of energy in or out. (A rock would be an example; a box full of gas is another.) Life is just the opposite. A plant, for example, absorbs sunlight and uses its energy to make complex sugar molecules while radiating heat back into the environment.


Understanding these complex systems “is the great unsolved problem in physics,” says Stephen Morris, a University of Toronto physicist. “How do we deal with these far-from-equilibrium systems which self-organize into amazing, complex things - like life?”